Neurobiology of Disease Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer’s Disease
نویسندگان
چکیده
Heather A. Born,1 Ji-Yoen Kim,1 Ricky R. Savjani,1,8 Pritam Das,9 Yuri A. Dabaghian,6,10 Qinxi Guo,7 Jong W. Yoo,2 Dorothy R. Schuler,11 John R. Cirrito,11 Hui Zheng,1,3,4,7 Todd E. Golde,12 Jeffrey L. Noebels,1,2,4 and Joanna L. Jankowsky1,2,5,7 1Department of Neuroscience, 2Department of Neurology, 3Department of Molecular and Cellular Biology, 4Department of Human and Molecular Genetics, 5Department of Neurosurgery, 6the Jan and Dan Duncan Neurological Research Institute, and 7the Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, 8Texas A&M Health Science Center, College Station, Texas 77843, 9Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, 10Department of Computational and Applied Mathematics, Rice University, Houston, Texas 77251, 11Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, and 12Department of Neuroscience, University of Florida, Gainesville, Florida 32610
منابع مشابه
Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.
Alzheimer's disease (AD) is associated with an elevated risk for seizures that may be fundamentally connected to cognitive dysfunction. Supporting this link, many mouse models for AD exhibit abnormal electroencephalogram (EEG) activity in addition to the expected neuropathology and cognitive deficits. Here, we used a controllable transgenic system to investigate how network changes develop and ...
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